Surround Sound® Technology

The Surround Sound system is provides a one-time, non-invasive procedure to treat hypertension. Surround Sound uses ultrasound imaging to robotically guide the delivery of focused ultrasound energy to treat renal nerves (renal denervation (RDN)). The system targets specific tissue while automatically tracking movement and continuously enabling therapy delivery. The company has completed three single-arm studies showing reduction of blood pressure in resistant hypertension patients and an excellent safety profile. The company is currently enrolling in the sham-controlled WAVE IV study outside the United States and is planning its WAVE V US/global study.

The initial clinical application addresses high blood pressure (hypertension) through ablation of the renal nerves. Renal nerves are located adjacent to the renal arteries, which provide blood flow to the kidneys. Renal nerves are part of the sympathetic nervous system and play a significant role in determining blood pressure. Clinical data have shown that ablation of renal nerves can result in profound and lasting reduction in hypertension in patients whose blood pressure is not adequately controlled by medication.

In contrast to catheter-based renal denervation systems, which rely on internal delivery of energy through the wall of the renal artery to ablate renal nerves, the Surround Sound system delivers the energy from outside the body non-invasively. The fully-integrated, self-contained system can be used in virtually any exam room in a hospital, office or clinic, and does not require a catheterization lab.

Ultrasound-based, non-invasive RDN has the potential to greatly reduce cost, lower risk, and improve access to millions of hypertension patients worldwide who are not adequately controlled by drug therapy.

Kona has a foundational intellectual property position in therapeutic ultrasound, with numerous US and International patent applications covering its platform technology. For more information, contact us at info@konamedical.com.

Issued US patents to date (other patents pending):

  • 8,137,274 A Method of Applying Heat To A Region Proximate To A Blood Vessel
  • 8,167,805 Systems And Methods For Ultrasound Applicator Station Keeping
  • 8,277,398 Methods And Devices To Target Vascular Targets With High Intensity Focused Ultrasound
  • 8,295,912 Method And System To Inhibit A Function Of A Nerve Traveling With An Artery
  • 8,372,009 System And Method For Treating A Therapeutic Site
  • 8,374,674 Nerve Treatment System
  • 8,388,535 Methods And Apparatus For Focused Ultrasound Application
  • 8,469,904 Energetic Modulation Of Nerves
  • 8,469,904 Energetic Modulation Of Nerves
  • 8,512,262 Energetic Modulation Of Nerves
  • 8,517,962 Energetic Modulation Of Nerves
  • 8,556,834 Flow Directed Heating Of Nervous Structures
  • 8,986,231 Energetic Modulation Of Nerves
  • 8,992,447 Energetic Modulation Of Nerves
  • 9,005,143 External Autonomic Modulation

Issued China patent to date (other International patents pending):

  • ZL 2011 2 0473542.2 A System for Applying Focused Ultrasound Energy to a Nerve Surrounding Artery of a Patient

Note: The Kona Surround Sound® system is investigational and is not yet approved for sale.